Question 1

8.00  Registration Open

Accepted Answer

Welcome coffee.
Please enjoy breakfast at your hotel prior to arriving at the venue.

Question 2

9.00 - 11.15 SESSION I : Oligonucleotide Therapeutics Education Workshop

Accepted Answer

Co-chairs: Alex Garanto, Ph.D., Radboud Univ. Medical Center & Chantal Ferguson, MD/Ph.D., Mass General Hospital   9.10-9.35: 		Overview of the field, how we have come to where we are now, Laura Sepp-Lorenzino, Ph.D., GNMmeds LLC9.35-10.00:	 The Expanding Universe of Nucleic Acid Modifications: Origins, Applications and Frontiers, Martin Egli, Ph.D., Vanderbilt University10.00-1025:	 Pharmacokinetics by Design: The Conjugate Toolkit, Vignesh Narayan Hariharan, Ph.D., Comanche Biopharma10.25-10.50: 	Models and controls: getting it right by learning from other people’s mistakes and experience, Annemieke Aartsma-Rus, Ph.D., Leiden University Medical Center10.50-11.15:	 How to shape the oligo field in an interphase Industry/Academia and how the future looks like, Art Levin, Ph.D., Avidity Biosciences

Question 3

9.00 - 11.30 SESSION II (PARALLEL SESSION): IND-CMC Insights for Early-Stage Oligonucleotide Innovators

Accepted Answer

Co-chairs:David Butler, Ph.D., Advisor, RNA Science and Technology Marc Lemaitre, Ph.D., ML_ConsultCMC workflow – a phase-appropriate strategy and execution, Hagen Cramer, Ph.D., QurAlisTranslating Nucleic Acid Therapeutics from Discovery to the Clinic: Practical CMC and CMO Engagement Strategies, Eduardo Paredes, Ph.D., Leal TherapeuticsRegulatory CMC Requirements for Oligonucleotide – A European Perspective, René Thürmer, Ph.D., BfArMUSP Reference Standards and Impurity Analytical Reference Materials for Oligonucleotide Quality Across Modalities, Sarita Kattel, US PharmacopeiaManufacturing for First in Human Clinical Trials: What Do You Really Need?, Kevin Fettes, Ph.D., FTS Pharma Consulting*Session to be continued after lunch breakSession Sponsor:

Question 4

11.30 - 13.30 Hosted Lunch

Accepted Answer

Hosted Lunch (for all participants)
&
Mentorship Program Lunch (by invitation)

Question 5

13.30 - 15.00 SESSION II Contd. (PARALLEL SESSION): IND - CMC Insights for Early-Stage Oligonucleotide Innovators

Accepted Answer

Co-chairs:David Butler, Ph.D., Advisor, RNA Science and Technology Marc Lemaitre, Ph.D., ML_ConsultPresentation title to be announced, Chris Li, Ph.D., HongeneControl Strategies for Therapeutic Oligonucleotides: Key Insights and Regulatory Expectations, Timo Pöstges-Janotta, Ph.D., BioSpringSession Sponsor:

Question 6

13.30 - 15.00 SESSION III: Next-Gen Early Career Scientist Workshop

Accepted Answer

Co-chairs: Daniel Knight, Ph.D. Candidate, Carleton University &Sarah Allen, Ph.D. Candidate, UMass Chan Medical School/RTISession Keynote:Strategic investments in RNA-based therapeutics at Novartis. Expanding therapeutic scope and clinical applicability, Dr. Malgorzata Gonciarz, Ph.D., NovartisShort Talks:·         Targeting HTLV-1 in the CNS: Antiviral siRNA Therapeutics for Glial Infection, Tiana Wang, Ph.D. Student, The Kirby Institute, University of New South Wales (UNSW)·         ERASOR: A platform to select antisense oligonucleotides for personalized treatment of genetic diseases, Emilio Harris-Mostert, Ph.D. Candidate, Erasmus MC·         MSH3-Targeted Divalent siRNA Defines a Timing-Dependent Window for Somatic Repeat Expansion Suppression, Emily G. Knox, Postdoc, Postdoc, UMass Chan Medical School·         One Scaffold, Many Targets: Fully Modified RNA Nanostructures for Multi-Gene Silencing Beyond the Liver, Hassan H. Fakih, Ph.D, UMass Chan Medical School·         Preclinical Advancement of Antisense Oligonucleotide Therapy for DFNA9 Using Intracochlear and Intratympanic Delivery Approaches, Fien Aben, Ph.D. Fellow, University of Antwerp

Question 7

15.00 - 15.30  Refreshment Break

Accepted Answer

Refreshment Break

Question 8

15.30 - 16.45 CAREER EVENT

Accepted Answer

Co-Chairs:Emilio Harris-Mostert, Ph.D., Candidate, Erasmus Medical Center &Sarah Allen, Ph.D., Candidate, UMass Chan Medical School / RTIDo you need help navigating the current job market or making the perfect CV? Join the Career Event to discuss these and many other topics in a roundtable setting and learn from experts in the  OTS field. *Register your attendance during the registration process.

Question 9

16.45 - 17.30  SESSION IV: Opening Session and Keynote Address

Accepted Answer

Keynote Address:My Journey across the RNA World: from Ribozymes to TMOs,  by Thomas R. Cech, Department of Biochemistry and BioFrontiers Institute, University of Colorado Boulder

Question 10

17.30 - 19.30 Welcome Reception with Exhibitors (no Poster hosting)

Accepted Answer

Welcome Reception in at the Colorado Convention Center, Mile High Ballroom

Reception Sponsor:

Question 11

20.00 - 22.00 Early Career Social Meet Up

Accepted Answer

EARLY CAREER SCIENTIST SOCIAL MEET UP
(Open to registered students, post-docs, and trainees – included in the registration fee)

Connect, unwind, and expand your network in a relaxed and fun setting.
Join us at Lucky Strike Denver for an evening of casual networking, games, and great conversations.

Location: 
Lucky Strike Denver (5mins walk from the Convention Center)
https://www.luckystrikeent.com/
500 16th St Mall #340, Denver, CO 80202

Social Meet Up Sponsor:

Agenda

8.00 Registration Open