Agenda

Refreshment Break

Welcome coffee. Please enjoy breakfast at your hotel prior to arriving at the venue.

Co-chairs: Alex Garanto, Ph.D., Radboud Univ. Medical Center & Chantal Ferguson, MD/Ph.D., Mass General Hospital Overview of the field, how we have come to where we are now, Laura Sepp-Lorenzino, Ph.D., GNMmeds LLC The Expanding Universe of Nucleic Acid Modifications: Origins, Applications and Frontiers, Martin Egli, Ph.D., Vanderbilt University Modifications and Conjugations, Hassan H. Fakih, Ph.D., UMASS Chan Medical School Models and controls: getting it right by learning from other people’s mistakes and experience, Annemieke Aartsma-Rus, Ph.D., Leiden University Medical Center How to shape the oligo field in an interphase Industry/Academia and how the future looks like, Art Levin, Ph.D., Avidity Biosciences

Co-chairs: David Butler, Ph.D., Hongene Biotech & Marc Lemaitre, Ph.D., ML_Consult CMC workflow – a phase-appropriate strategy and execution, Hagen Cramer, Ph.D., QurAlis Presentation title to be announced, Eduardo Paredes, Ph.D., Leal Therapeutics Regulatory CMC Requirements for Oligonucleotide – A European Perspective, René Thürmer, Ph.D., BfArM Oligonucleotide Starting Materials: Quality and Impurities, Sarita Kattel, Ph.D., US Pharmacopeia Presentation title to be announced, Kevin Fettes, Ph.D., FTS Pharma Consulting *Session to be continued after lunch break Session Sponsor:

Hosted Lunch (for all participants) & Mentorship Program Lunch (by invitation)

Co-chairs: David Butler, Ph.D., Hongene Biotech & Marc Lemaitre, Ph.D., ML_Consult siRNA Impurity Analytical Control Strategy, Lianxiu Guan, Ph.D., Amgen Presentation title to be announced, Chris Li, Ph.D., Hongene *additional speakers to be confirmed shortly Session Sponsor:

Co-chairs: Ilaria Brentari, Postdoc, University of Trento & David Knight, Ph.D. Candidate, Carleton University Session Keynote: Strategic investments in RNA-based therapeutics at Novartis. Expanding therapeutic scope and clinical applicability, Dr. Malgorzata Gonciarz, Ph.D., Novartis

Refreshment Break

Co-Chairs: Emilio Harris-Mostert, Ph.D., Candidate, Erasmus Medical Center & Sarah Allen, Ph.D., Candidate, UMass Chan Medical School / RTI Do you need help navigating the current job market or making the perfect CV? Join the Career Event to discuss these and many other topics in a roundtable setting and learn from experts in the  OTS field. *Register your attendance during the registration process.

Keynote Address by Thomas R. Cech, Ph.D., Distinguished Professor of Biochemistry, Investigator, Howard Hughes Medical Institute BioFrontiers Institute, University of Colorado Boulder

Welcome Reception in at the Colorado Convention Center, Mile High Ballroom Reception Sponsor:

EARLY CAREER SCIENTIST SOCIAL MEET UP (Open to registered students, post-docs, and trainees – included in the registration fee) Connect, unwind, and expand your network in a relaxed and fun setting. Join us at Lucky Strike Denver for an evening of casual networking, games, and great conversations. Location:  Lucky Strike Denver (5mins walk from the Convention Center) https://www.luckystrikeent.com/ 500 16th St Mall #340, Denver, CO 80202 Social Meet Up Sponsor: