Please enjoy breakfast at your hotel prior to arriving at the venue.

Co-chairs: Alex Garanto, Ph.D., Radboud Univ. Medical Center & Chantal Ferguson, MD/Ph.D., Mass General Hospital9:00-9:10            Opening remarks 9:10-9:35            Overview of the field, how we have come to where we are now, Laura Sepp-Lorenzino, Ph.D., GNMmeds LLC 9:35-10:00          The Expanding Universe of Nucleic Acid Modifications: Origins, Applications and Frontiers, Martin Egli, Ph.D., Vanderbilt University 10:00-10:25       Pharmacokinetics by Design: The Conjugate Toolkit, Vignesh Narayan Hariharan, Ph.D., Comanche Biopharma 10:25-10:50       Models and controls: getting it right by learning from other people’s mistakes and experience, Annemieke Aartsma-Rus, Ph.D., Leiden University Medical Center 10:50-11:15       Shaping the Oligonucleotide Field: The Industry-Academia Interface and What Comes Next, Art Levin, Ph.D., Avidity Biosciences

Co-chairs:David Butler, Ph.D., Advisor, RNA Science and Technology & Marc Lemaitre, Ph.D., ML_Consult9:00-9:30CMC workflow – a phase-appropriate strategy and execution, Hagen Cramer, Ph.D., QurAlis 9:30-10:00   Translating Nucleic Acid Therapeutics from Discovery to the Clinic: Practical CMC and CMO Engagement Strategies, Eduardo Paredes, Ph.D., Leal Therapeutics 10:00-10:30 Regulatory CMC Requirements for Oligonucleotide – A European Perspective, René Thürmer, Ph.D., BfArM 10:30-11:00  USP Reference Standards and Impurity Analytical Reference Materials for Oligonucleotide Quality Across Modalities, Sarita Kattel, US Pharmacopeia 11:00-11:30  Manufacturing for First in Human Clinical Trials: What Do You Really Need?, Kevin Fettes, Ph.D., FTS Pharma Consulting *Session to be continued after lunch breakSession Sponsor:

Hosted Lunch (for all participants)&Mentorship Program Lunch (by invitation)

Co-chairs:David Butler, Ph.D., Advisor, RNA Science and Technology &Marc Lemaitre, Ph.D., ML_Consult1:30-2:00            Learnings from Implementing CMC Analytical Control Strategies for Early-Stage Oligonucleotide Programs, Huijun Tian, Ph.D., QurAlis 2:00-2:30             Chemoenzymatic Ligation for Complex Oligonucleotides, Chris (Xiaocen) Li, Ph.D., Hongene Biotech 2:30-3:00             Control Strategies for Therapeutic Oligonucleotides: Key Insights and Regulatory Expectations, Timo Pöstges-Janotta, Ph.D., BioSpringSession Sponsor:

Co-chairs: Daniel Knight, Ph.D. Candidate, Carleton University &Sarah Allen, Ph.D. Candidate, UMass Chan Medical School/RTISession Keynote:1:30-1:50Strategic investments in RNA-based therapeutics at Novartis. Expanding therapeutic scope and clinical applicability, Dr. Malgorzata Gonciarz, Ph.D., NovartisShort Talks:1:50-2:05 Targeting HTLV-1 in the CNS: Antiviral siRNA Therapeutics for Glial Infection, Tiana Wang, Ph.D. Student, The Kirby Institute, University of New South Wales (UNSW)2:05-2:20             ERASOR: A platform to select antisense oligonucleotides for personalized treatment of genetic diseases, Emilio Harris-Mostert, Ph.D. Candidate, Erasmus Medical2:20-2:35             MSH3-Targeted Divalent siRNA Defines a Timing-Dependent Window for Somatic Repeat Expansion Suppression, Emily G. Knox, Postdoc, UMass Chan Medical School2:35-2:50             One Scaffold, Many Targets: Fully Modified RNA Nanostructures for Multi-Gene Silencing Beyond the Liver, Hassan H. Fakih, Ph.D., UMass Chan Medical School2:50-3:05             Preclinical Advancement of Antisense Oligonucleotide Therapy for DFNA9 Using Intracochlear and Intratympanic Delivery Approaches, Fien Aben, Ph.D. Fellow, University of Antwerp

Refreshment Break

Co-Chairs:Emilio Harris-Mostert, Ph.D., Candidate, Erasmus Medical Center &Sarah Allen, Ph.D., Candidate, UMass Chan Medical School / RTIEngage in roundtable discussions with moderators who have followed compelling career paths of their own. Designed to spark new connections, this session offers a personal, hands-on way to explore career opportunities and hear firsthand what different paths in the field can look like. Roundtable topics:Applying to jobs | Recognizing the values of your ideas | Building an expertise that matters | Building meaningful connections | Psychology of being a scientist | Crossing disciplines | Industry culture shock | Power of negotiation | Communicating your science | Work-life balance | Navigating the changing scientific landscape *Register your attendance during the registration process.

Welcome and Opening by: Rebecca Miles, Ph.D., BaseCure Therapeutics & President OTS Keynote Address:Introduction by: Anastasia Khvorova, Ph.D., RNA Therapeutic Institute/UMass Chan Medical SchoolMy Journey across the RNA World: from Ribozymes to TMOs, by Thomas R. Cech, Department of Biochemistry and BioFrontiers Institute, University of Colorado Boulder

6:00PM – 7:00PM Book SigningThe Catalyst: RNA and the Quest to Unlock Life's Deepest SecretsThomas R. Cech, Nobel LaureatePre-ordered copies can be signed by the author during the Welcome Reception, Mile High Ballroom.Book Signing sponsored by :

Welcome Reception in at the Colorado Convention Center, Mile High Ballroom Reception Sponsor:

EARLY CAREER SCIENTIST SOCIAL MEET UP(Open to registered students, post-docs, and trainees – included in the registration fee)Connect, unwind, and expand your network in a relaxed and fun setting.Join us at Lucky Strike Denver for an evening of casual networking, games, and great conversations.Location: Lucky Strike Denver (5mins walk from the Convention Center)https://www.luckystrikeent.com/500 16th St Mall #340, Denver, CO 80202Social Meet Up Sponsor: